Systems Biology University of Freiburg
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Dr. Christian Tönsing

Faculty of Mathematics and Physics
Institute of Physics
University of Freiburg
 
Hermann-Herder-Str. 3
79104 Freiburg i.Br.
Germany

christian.toensing -at- fdm.uni-freiburg.de


phone: +49 761 203 8532
or +49 761 203 7633

office: Physics high-rise, room 208.1


 
Research interests

- Parameter estimation and optimal experimental design methods for biochemical reaction network models
- Sloppiness in ordinary differential equation (ODE) models
- Mathematical modelling of erythropoiesis
- Analysis of reverse phase protein lysate microarray (RPPA) data
- Hypoxia in breast cancer
- Profile likelihood analyses
- Infectious disease models (ODEs)
- Dynamical modelling frameworks (d2d)
- Optimal paths in high dimensional likelihood landscapes


Publications

Adlung L.*, Stapor P.*, Tönsing C.*, Schmiester L., Schwarzmüller L.E., Wang D., Timmer J., Klingmüller U., Hasenauer J., Schilling M.
Cell-to-cell variability in JAK2/STAT5 pathway components and cytoplasmic volumes define survival threshold in erythroid progenitor cells
Cell Reports 36, 109507 (2021)
doi: 10.1016/j.celrep.2021.109507

Wieland F.-G., Hauber A. L., Rosenblatt M., Tönsing C., Timmer J.
Structural and practical identifiability
Current Opinion in Systems Biology 25:60-69 (2021)
doi: 10.1016/j.coisb.2021.03.005

Tönsing C.*, Timmer J., Kreutz C.
Optimal Paths Between Parameter Estimates in Nonlinear ODE Systems Using the Nudged Elastic Band Method
Frontiers in Physics, 7:149, (2019)
doi: 10.3389/fphy.2019.00149
NEB code (d2d)
Swameye NEB example (d2d)

Bernhardt S.*, Tönsing C.*, Mitra D., Erdem N., Müller-Decker K., Korf U., Kreutz C., Timmer J., Wiemann S.
Functional proteomics of breast cancer metabolism identifies GLUL as responder during hypoxic adaptation
Journal of Proteome Research, 18 (3), 1352-1362. (2019)
doi: 10.1021/acs.jproteome.8b00944

Tönsing C.*, Timmer J., Kreutz C.
Profile likelihood-based analyses of infectious disease models   (pdf)
Statistical Methods in Medical Research, 27(7), 1979–1998. (2018)
doi: 10.1177/0962280217746444
Influenza data, model & scripts
Zika Virus data, models & scripts

A. Raue, B. Steiert, M. Schelker, C. Kreutz, T. Maiwald, H. Hass, J. Vanlier, C. Tönsing, L. Adlung, R. Engesser, W. Mader, T. Heinemann, J. Hasenauer, M. Schilling, T. Höfer, E. Klipp, F. Theis, U. Klingmüller, B. Schöberl, J. Timmer
Data2Dynamics: a modeling environment tailored to parameter estimation in dynamical systems
Bioinformatics. btv405 (2015)
doi:10.1093/bioinformatics/btv405

Tönsing C.*, Timmer J., Kreutz C.
Cause and cure of sloppiness in ordinary differential equation models
Phys. Rev. E 90, 023303 (2014)
doi: 10.1103/PhysRevE.90.023303

* main authors

Reviewer for:

- Royal Society Open Science
- Journal of the American Statistical Association
- Bioinformatics
- BMC Bioinformatics


Conferences
11/2019 Poster
Optimal path between parameter estimates in nonlinear ODE systems
INCOME2019 Conference: Integrative pathway modeling in systems biology and systems medicine, Berlin (GER)
05/2019 Poster Optimal paths between parameter estimates in nonlinear ODE systems
International Conference on Systems Biology of Human Disease 2019 (SBHD), Berlin (GER)
04/2019 Poster Optimal paths between parameter estimates in nonlinear ODE systems
Dutch Bioinformatics & Systems Biology Conference 2019, Lunteren (NL)
10/2018 Poster Optimal path between parameter estimates in nonlinear ODE systems
INCOME2018 Conference: Integrative pathway modeling in systems biology and systems medicine, Bernried (GER)
07/2018 Poster Optimal path between parameter estimates in nonlinear ODE systems
7th Conference on Systems biology of Mammalian Cells (SBMC), Bremen (GER)
03/2018 Talk Profile likelihood based analyses of infectious disease models
Frühjahrstagung Deutsche Physikalische Gesellschaft (DPG) 2018 Berlin, (GER)
09/2017 Invited Talk Cause and Cure of Sloppiness in Ordinary Differential Equation Models
ODE Modelling in Systems Biology, FRIAS Junior Researcher Conference, 2017 Freiburg, (GER)
03/2017 Talk Cause and Cure of Sloppiness in Ordinary Differential Equation Models
Frühjahrstagung Deutsche Physikalische Gesellschaft (DPG) 2017 Dresden, (GER)
04/2016 Poster Cause and Cure of Sloppiness in Ordinary Differential Equation Models
6th Conference on Systems Biology of Mammalian Cells (SBMC), Munich (GER)
07/2015 Lightning Talk & Poster
Cause and Cure of Sloppiness in Ordinary Differential Equation Models
International Conference on Systems Biology of Human Disease 2015 (SBHD), Heidelberg (GER)
06/2015 Talk & Poster Cause and Cure of Sloppiness in Ordinary Differential Equation Models
[BC]^2 Basel Compitational Biology Conference 2015, Basel (CH)
05/2014 Poster Cause and Cure of Sloppiness in Ordinary Differential Equation Models
5th Conference on Systems Biology of Mammalian Cells (SBMC), Berlin (GER)
03/2014 Talk & Poster On the Cause and Cure of Sloppiness in Ordinary Differential Equation Models
Advanced Lecture Course on Systems Biology 2014, Innsbruck (AT)
07/2013 Poster Using experimental design methods to reduce the Sloppiness of an ODE Model
International Conference on Systems Biology (ICSB) 2013, Copenhagen (DK)
07/2012 Poster Experimental design for parameter estimation: Are ODE models 'sloppy'?
4th Conference on Systems Biology of Mammalian Cells (SBMC), Leipzig (GER)
03/2012 Poster Experimental design for parameter estimation: Are ODE models 'sloppy'?
Helmholtz Alliance on Systems Biology Spring School 2012, Seeon (GER)
01/2012 Poster Experimental design for parameter estimation: Are ODE models 'sloppy'?
International Symposium on Quantitative Biology and Cytokine Signaling, Engelberg (CH)
10/2011 Attendance
06/2010
Attendance 3th Conference on Systems Biology of Mammalian Cells (SBMC), Freiburg (GER)




Curriculum Vitae:
05/2020 - now Postdoctoral researcher in the group of Prof. Dr. Jens Timmer
11/2013 - 05/2020
PhD student in the group of Prof. Dr. Jens Timmer
05/2013 - 10/2013 'Wissenschaftlicher Mitarbeiter' in the group of Prof. Dr. Jens Timmer
10/2011 - 04/2013 Diploma thesis in physics in the group of Prof. Dr. Jens Timmer
08/2009 - 04/2010
10/2008 - 04/2013
Graduate student in physics at Albert-Ludwigs-Universität Freiburg
10/2006 - 10/2008 Undergraduate Student in physics at Albert-Ludwigs-Universität Freiburg
08/2005 - 04/2006 Civilian service at the German Red Cross (DRK), Bad Lippspringe
06/2005 Abitur at Gymnasium Theodorianum, Paderborn





Teaching

SS 2021 Organisation der Übungen zu "Mathematik 1 für Studierende der Physik"
WS 2020/21 Organisation und Tutor der Übungen zu "Dynamical Systems in Biology"
SS 2016 Tutor Übungen zu Experimentalphysik 2
WS 2015/16 Tutor Übungen zu Analysis für Physiker
SS 2015 Organisation und Tutor der Übungen zu "Statistik und Numerik"
WS 2014/15 Tutor Übungen zu Theoretische Physik 1
SS 2014 Tutor Übungen zu Experimentalphysik 2
WS 2013/14 Tutor Übungen zu Theoretische Physik 3: Elektrodynamik und SRT
WS 2012/13 Organisation und Tutor der Übungen zu "Mathematik für Bioinformatik und Systembiologie"
Summer 2012 Tutor Physikalisches Anfängerpraktikum
Spring 2012 Tutor Physikalisches Anfängerpraktikum
WS 2011/12 Tutor Übungen zur Experimentalphysik 1
Oktober 2011 Tutor Mathematik Vorkurs für Physiker
Spring 2011 Tutor Physikalisches Anfängerpraktikum
SS 2010 Tutor Physikalisches Anfängerpraktikum
SS 2009 Tutor Physikalisches Anfängerpraktikum



Links:


Group of Dr. Clemens Kreutz: Methods of Modelling and Bioinformatics in Systems Biomedicine (MSB), Institute of Medical Biometry and Statistics (IMBI)

Group of Prof. Dr. Jens Timmer: Data Analysis and Modeling of Dynamic Processes in the Life Sciences



D2D - data 2 dynamics software